AOD-9604 5mg

Each AOD-9604 vial from Onyx Research holds 5mg of research compound, freeze-dried and crimp-sealed. It’s a modified hGH fragment. Onyx Research supplies it for in-vitro research.

About AOD-9604

AOD-9604 is a modified fragment of human growth hormone (residues 177-191 with an added tyrosine). It was developed at Monash University to study fat metabolism without GH’s effects on growth or IGF-1.

Metabolic Pharmaceuticals took it into trials.

Mechanism of action

Growth hormone has a region near its C-terminal end, residues 177 to 191, that seems to account for its effect on fat breakdown. AOD-9604 is that fragment with a tyrosine added at the front.

In animal studies it increased lipolysis and reduced lipogenesis in fat cells. It doesn’t bind the growth hormone receptor the way full GH does, and it didn’t raise IGF-1 in trials, which is what made it interesting as a tool for separating GH’s fat effects from its growth effects.

AOD-9604 details

• Compound: AOD-9604
• Also known as: hGH fragment 177-191
• CAS number: 221231-10-3
• Molecular formula: C78H123N23O23S2
• Molecular weight: 1,815.1 g/mol
• Structure: hGH fragment 177-191 with an added N-terminal tyrosine
• Amount per vial: 5mg
• Form: lyophilized (freeze-dried) powder in a crimp-sealed glass vial
• SKU: ONYX-AOD-5
• Use: laboratory research only

Published studies

Heffernan and colleagues reported in 2001 that it reduced body fat in obese mice.

Phase 2b trials didn’t show significant weight loss compared with placebo.

The papers mentioned here are listed on PubMed, run by the National Institutes of Health. Start with this AOD-9604 search.

Alternatives labs compare it with

In one line, AOD-9604 is the 176-191 tail of growth hormone, studied for fat breakdown. The closest alternatives work differently:

• GLP-3 RT (GLP-3 RT, retatrutide) acts on three receptors: GIP, GLP-1 and glucagon
• Cagrilintide is a long-acting amylin analog, a fullness signal that runs apart from GLP-1
• GLP-1 SM (GLP-1 SM, semaglutide) is a once-weekly GLP-1 receptor agonist with a fatty-acid side chain
• MOTS-c is a short peptide encoded in mitochondrial DNA that switches on AMPK
• GLP-2 TZ (GLP-2 TZ, tirzepatide) acts on two incretin receptors, GIP and GLP-1

Metabolic research comes at weight from several directions: incretin receptors, amylin, glucagon, a growth hormone fragment and the mitochondria. Every one of them is in stock in our weight loss peptides.

Checking your vials

Each vial carries the black and white Onyx Research label with the compound, the amount, 99% purity and the research-use line. Check that the name and amount match your order and that the cap and crimp are tight.

The powder should look dry and pale, either as a solid cake or loose granules. If the cake has crumbled in the box, that’s expected. Powder that looks wet, gummy or off-color is not, so keep that vial out of use and send us a photo.

Log the date the vial arrived and, later, when and how you mixed it. It’s quick, and it saves a lot of guesswork if something goes wrong.

AOD-9604 dilution chart

Pick your water volume first and the strength follows from it. With the 5mg vial:

• Add 1mL: 5mg/mL (500mcg per 0.1mL, or 10 units on a U-100 syringe)
• Add 2mL: 2.5mg/mL (250mcg per 0.1mL, or 10 units on a U-100 syringe)
• Add 3mL: 1.67mg/mL (166.7mcg per 0.1mL, or 10 units on a U-100 syringe)

Give a cold vial five minutes on the bench, then swab the top. Let the bacteriostatic water trickle down the side and roll the vial gently between your palms. It should turn clear within a minute or two.

Keeping the vial stable

Two rules cover AOD-9604 storage: powder in the freezer, solution in the fridge. Keep both away from light and damp, since those break freeze-dried peptides down fastest.

Store mixed vials upright, so the liquid stays off the rubber stopper.

Often bought with it

• Tesamorelin 10mg, a GHRH analog
• GLP-2 TZ 10mg (Tirzepatide), a GIP/GLP-1 agonist
• GLP-3 RT (Retatrutide), a triple agonist
• MOTS-c 10mg, a mitochondrial peptide
• GLP-1 SM 10mg (Semaglutide), a GLP-1 agonist

For more options, open our weight loss peptides or head back to the Onyx Research home page.

Frequently asked questions

How much is in a AOD-9604 vial?

5mg, as printed on the label.

Is it for human use?

No. Onyx Research sells it strictly for lab research, never for people or animals.

Is it in stock?

Yes, AOD-9604 is in stock today.

Is there a crypto discount?

Yes. Onyx Research gives an extra discount on orders paid with crypto, applied at checkout.

Do you charge for shipping?

Shipping is free on all orders, wherever you are.

Buy AOD-9604 today

Order AOD-9604 now from $70.00. It’s in stock, and shipping is free on every order.

Choose cryptocurrency at checkout and an extra discount comes off the total.

Building a larger order? See what else is in our weight loss peptides.

Research use only. Onyx Research supplies this material to qualified labs for in-vitro work. It’s not a medicine, supplement, food or cosmetic, and it must not be given to people or animals. No statement here has been reviewed by the FDA.