GLP-1 SM 10mg (Semaglutide)

GLP-1 SM is a sealed vial with 10mg of freeze-dried semaglutide. It’s a GLP-1 receptor agonist. It’s sold for laboratory research only.

GLP-1 SM is how our label names semaglutide. It acts on one receptor, GLP-1, and SM is short for the compound itself.

What is GLP-1 SM (semaglutide)?

Semaglutide is a GLP-1 receptor agonist from Novo Nordisk. It’s 94% identical to human GLP-1, with two changes that matter: an amino acid swap at position 8 that blocks the enzyme DPP-4, and a C18 fatty diacid chain that binds albumin. Together they take the half-life from about two minutes to about a week.

It’s approved as Ozempic and Rybelsus for type 2 diabetes and as Wegovy for weight management, which makes it the most studied compound in the GLP-1 class.

How GLP-1 SM works

GLP-1 is a gut hormone released after a meal. It tells the pancreas to release insulin, but only when blood sugar is high, and it slows how fast the stomach empties. Receptors in the hypothalamus pick it up too, which is where its effect on appetite comes from.

Natural GLP-1 is broken down by the enzyme DPP-4 within a couple of minutes. Semaglutide swaps one amino acid to resist DPP-4 and carries a fatty acid that binds albumin in the blood. Together those changes stretch its half-life to about a week, which is why it’s studied as a once-weekly compound.

GLP-1 SM details

• Compound: GLP-1 SM (semaglutide)
• Onyx Research label code: GLP-1 SM
• CAS number: 910463-68-2
• Molecular formula: C187H291N45O59
• Molecular weight: 4,113.6 g/mol
• Structure: 31 amino acids with a C18 fatty diacid side chain
• Amount per vial: 10mg
• Form: lyophilized (freeze-dried) powder in a crimp-sealed glass vial
• SKU: ONYX-GLP1SM-10
• Use: laboratory research only

What the research reports

The STEP 1 trial (Wilding and colleagues, New England Journal of Medicine, 2021) reported average weight loss of 14.9% at 68 weeks against 2.4% on placebo.

The SELECT trial (Lincoff and colleagues, 2023) followed more than 17,000 adults with heart disease and overweight but no diabetes, and found a 20% lower rate of major cardiovascular events on semaglutide.

The papers mentioned here are listed on PubMed, run by the National Institutes of Health. Start with this Semaglutide search.

Similar research compounds

In one line, GLP-1 SM is a once-weekly GLP-1 receptor agonist with a fatty-acid side chain. The closest alternatives work differently:

• GLP-3 RT (GLP-3 RT, retatrutide) acts on three receptors: GIP, GLP-1 and glucagon
• Cagrilintide is a long-acting amylin analog, a fullness signal that runs apart from GLP-1
• GLP-2 TZ (GLP-2 TZ, tirzepatide) acts on two incretin receptors, GIP and GLP-1
• MOTS-c is a short peptide encoded in mitochondrial DNA that switches on AMPK
• AOD-9604 is the 176-191 tail of growth hormone, studied for fat breakdown

Metabolic research comes at weight from several directions: incretin receptors, amylin, glucagon, a growth hormone fragment and the mitochondria. Every one of them is in stock in our weight loss peptides.

When your order arrives

The Onyx Research label names the compound and the amount. Compare both with your order confirmation, and check the crimp seal before the vial goes into storage.

The powder should look dry and pale, either as a solid cake or loose granules. If the cake has crumbled in the box, that’s expected. Powder that looks wet, gummy or off-color is not, so keep that vial out of use and send us a photo.

A one-line note per vial is enough: date received, date mixed and how much diluent went in.

Reconstitution chart and steps

These figures use the 10mg vial. For a bigger vial, multiply by the size difference.

• Add 1mL: 10mg/mL (1,000mcg per 0.1mL, or 10 units on a U-100 syringe)
• Add 2mL: 5mg/mL (500mcg per 0.1mL, or 10 units on a U-100 syringe)
• Add 3mL: 3.33mg/mL (333.3mcg per 0.1mL, or 10 units on a U-100 syringe)

Give a cold vial five minutes on the bench, then swab the top. Let the bacteriostatic water trickle down the side and roll the vial gently between your palms. It should turn clear within a minute or two.

Storing GLP-1 SM

Sealed GLP-1 SM lasts longest frozen at -20°C and dark. The fridge is fine for short spells. Mixed solution stays at 2 to 8°C and should be used within roughly 28 days.

Store mixed vials upright, so the liquid stays off the rubber stopper.

Often bought with it

• MOTS-c 10mg, a mitochondrial peptide
• Cagrilintide 10mg, an amylin analog
• GLP-3 RT (Retatrutide), a triple agonist
• AOD-9604 5mg, an hGH fragment
• GLP-2 TZ 10mg (Tirzepatide), a GIP/GLP-1 agonist

See everything in our weight loss peptides, or start from the Onyx Research home page to browse every category.

Questions people ask

How much is in a GLP-1 SM vial?

10mg, as printed on the label.

Is there a crypto discount?

Yes. Onyx Research gives an extra discount on orders paid with crypto, applied at checkout.

Do you charge for shipping?

No. Onyx Research ships every order free of charge, to the US and abroad.

How does ordering work?

Add it to the cart with anything else you need, then check out. Everything ships together.

What is in GLP-1 SM?

Semaglutide. GLP-1 SM is the name printed on the Onyx Research label.

Buy GLP-1 SM from Onyx Research

Add GLP-1 SM to your cart for $80.00. It’s in stock, and Onyx Research ships it free to the US, Canada, Europe, Australia and beyond.

Paying with crypto? Choose it at checkout for an extra discount on the whole order.

Building a larger order? See what else is in our weight loss peptides.

Research use only. Onyx Research supplies this material to qualified labs for in-vitro work. It’s not a medicine, supplement, food or cosmetic, and it must not be given to people or animals. No statement here has been reviewed by the FDA.