MK-677 Capsules 12.5mg (60 Count)

Each capsule in this MK-677 bottle contains 12.5mg of MK-677, 60 to a bottle. That’s 750mg of MK-677 per bottle. MK-677 is an orally active nonpeptide growth hormone secretagogue. It’s meant for lab and analytical work only.

Capsules need no mixing. Each one is filled with a set amount, so you skip the water, the syringe and the arithmetic.

This compound isn’t a peptide. It’s a small molecule that copies ghrelin’s action, which is why it fits in a capsule and still shows up in growth hormone research next to our peptide vials.

What is MK-677 (ibutamoren)?

MK-677 (ibutamoren) is an orally active, nonpeptide growth hormone secretagogue developed by Merck. It mimics ghrelin at the GHS-R1a receptor, raising growth hormone and IGF-1. It’s often sold next to SARMs, but it isn’t one.

It was never approved as a medicine, and it’s on the WADA prohibited list.

How it works

MK-677 binds GHS-R1a, the same receptor as ghrelin and the GHRP peptides, in the pituitary and hypothalamus. That boosts the size of natural GH pulses and lifts IGF-1 from the liver.

Because it’s a small molecule, not a peptide, it survives digestion and lasts about a day, which is what made it attractive as an oral research tool. The same receptor drives hunger, so appetite goes up too.

Specifications

• Compound: MK-677 (ibutamoren)
• Amount per capsule: 12.5mg
• Count: 60 capsules per bottle
• Form: dry-fill capsules
• CAS number: 159634-47-6
• Molecular formula: C27H36N4O5S
• Molecular weight: 528.7 g/mol
• SKU: ONYX-MK677-60
• Use: laboratory research only

Planning a study with capsules

Most handling mistakes happen while weighing or diluting. A capsule format removes both steps, which also makes a protocol simple to pass to a colleague.

Every step up or down is another 12.5mg. You can open and split a capsule, but then you lose the consistency that made capsules attractive.

One bottle holds 60 capsules: 60 days at one a day, or 30 days at two. Use that to work out how many bottles your study needs.

Storage and handling

Keep the lid tight and the bottle somewhere cool, dry and out of the sun. Leave any desiccant pack inside. Dry gloves stop moisture from softening the shells.

Note the date the bottle arrived and the date you opened it. If you portion capsules out to different experiments, label each portion.

Published studies

Nass and colleagues ran a two-year trial in healthy older adults, published in the Annals of Internal Medicine in 2008. MK-677 raised GH and IGF-1 to levels seen in young adults and increased fat-free mass, with rises in fasting glucose noted.

Earlier Merck studies by Chapman and colleagues described how it raises GH while keeping the normal pulse pattern.

The papers are free to read via this PubMed search for MK-677 from the U.S. National Library of Medicine.

Ordering MK-677

Work out the total number of doses and buy enough the product in one order. One order means one set of material to account for when you compare results.

Other research capsules and tablets

• RAD-140 Capsules 10mg: 10mg of RAD-140 per capsule
• Enclomiphene Capsules 12.5mg (60 Count): 12.5mg of Enclomiphene per capsule

The full solid-dose range is in our research capsules.

Often bought with it

• Enclomiphene Capsules 12.5mg (60 Count), pre-measured solid doses
• RAD-140 Capsules 10mg, pre-measured solid doses
• IGF-1 LR3 1mg, an IGF-1 analog
• Tesamorelin 10mg, a GHRH analog
• Sermorelin 5mg, a GHRH analog

For more options, open our research capsules and growth hormone peptides or head back to the Onyx Research home page.

Questions people ask

How much is in each capsule?

12.5mg of MK-677, with 60 per bottle.

Do you charge for shipping?

No. Shipping is free on every order, and we ship worldwide.

How does ordering work?

Choose the size, press add to cart and go through checkout. You can add bacteriostatic water and anything else to the same order.

Do the capsules need mixing?

No. Each capsule is a pre-measured solid dose.

Is there a crypto discount?

Yes. Pay with cryptocurrency at checkout and an extra discount comes off your order.

Buy MK-677 from Onyx Research

Order MK-677 now from $115.00. It’s in stock, and shipping is free on every order.

Choose cryptocurrency at checkout and an extra discount comes off the total.

Many labs pair it with something from our research capsules and growth hormone peptides.

Research use only. Onyx Research supplies this material to qualified labs for in-vitro work. It’s not a medicine, supplement, food or cosmetic, and it must not be given to people or animals. No statement here has been reviewed by the FDA.